Fig. 3

In vivo imaging of cerebrovascular disease model using optical-resolution photoacoustic microscopy (OR-PAM). a, b PA images of normal and glioma mouse brains, respectively [55]. The tumor core is indicated by the arrow in b. c, d PA images of mouse brain under ischemia and perfusion, respectively [57]. The white arrows reveal an obvious change in diameter and intensity of a single vessel due to ischemia and perfusion